Associations between adiposity related phenotypes and genetic

here Peroxisome proliferator activated receptor gamma (PPAR gamma) and peroxisome proliferator activated receptor delta (PPAR delta) are promising candidate genes for obesity. Associations between adiposity related phenotypes and genetic variation in PPAR gamma (Pro12Ala and C1431T), as well as PPAR delta (T+294C) were assessed in 2,102 Greek children aged 1 6 years, as part of a large scale epidemiological study (Growth, Exercise and Nutrition Epidemiological Study In preSchoolers). In girls aged 3 4 years, the Ala12 allele was associated with higher mid upper arm (P = 0.010) and hip (P = 0.005) circumferences, as well as subscapular (P = 0.008) and total skinfolds (P = 0.011) that explained 2.0, 3.7, 2.1, and 1.9% of the phenotypic variance, respectively, while the T1431 allele was associated with higher mean values for waist circumference (P = 0.018) and suprailiac skinfold (P = 0.017), genotype accounting for 1.6% of the variance in both phenotypes.

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