Hermann Kolbe discovered synthetic salicylic acid in 1874

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In the 1800s, researchers across Europe explored salicylic acid. French pharmacist Henri Leroux isolated it in 1829, Rouech writes. Hermann Kolbe discovered synthetic salicylic acid in 1874, but when administered often in large doses, patients experienced nausea and vomiting, and some even went into a coma.

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