Breathe in the fresh air. Look up at the sky. Appreciate the huge world around you and that you’re just a tiny little addition to it. The Lahore Biennale Foundation is an independent nonprofit organization that actively supports art projects in Pakistan through visual expression and experience. This year the Biennale titled ‘between the Sun and Moon’ is curated by Hoor Al Qasimi, the President and Director of Sharjah Art Foundation. The second edition will take place at selected areas of Lahore from 26th January till 29th February.
Analysis of these point mutations suggests that Hel308 may act in regulating the pathway choice for the resolution of homologous recombination intermediates.This study showed that H. Volcanii contains a second Hel308 helicase named Hel308b, which lacks the ‘auto inhibitory’ domain 5 found in canonical Hel308 helicases. Deletion of hel308b does not lead to sensitivity to DNA inter strand crosslinks but does result in defects in homologous recombination..
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Structurally the Orf C terminus consists of a helix with a flexible tail that protrudes from each side of the dimer and could serve as a binding site for either SSB or DNA. Eliminating the six residue flexible tail (C6) or the entire helix (C19) had no significant impact on the Orf SSB interaction. However, the OrfC6 protein exhibited reduced DNA binding, a feature shared by single amino acid substitutions within (W141F) or adjacent (R140A) to this region.
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